[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"item-306":3,"related-306":69},{"id":4,"title":5,"url":6,"summary":7,"summary_zh":8,"content":9,"source_name":10,"source_url":8,"published_at":11,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":15,"score_detail":16,"sources":24,"tags":26,"primary_topic":33,"secondary_topics":39,"classification":40,"search_phrases":64,"slug":67,"view_count":55,"doi":8,"paper":8,"created_at":68},306,"中国农科院烟草所研发新型双金属人工水解酶——生物膜清除率超80%、杀菌率超85%,登《德国应用化学》封面","https:\u002F\u002Fwww.toutiao.com\u002Farticle\u002F7670743194199441983\u002F","中国农业科学院烟草研究所烟草病虫害绿色防控创新团队成功研发一种新型双金属人工水解酶,将高活性Ce4+引入金属有机框架,构建具有双金属共定位活性中心的人工水解酶。该酶可高效水解糖苷键、实现对细菌生物膜多糖骨架的靶向降解,生物膜清除率超80%,杀菌率超85%。相关成果发表在国际顶级期刊《德国应用化学》(Angewandte Chemie International Edition, IF=17.6),获选为当期封面文章并被列为期刊热点论文。",null,"## 农科院烟草所研发出新型双金属人工水解酶，开辟细菌性病害防控药剂创制新路径\n\n2026-08-06 10:41·[世界农化网](https:\u002F\u002Fwww.toutiao.com\u002Fc\u002Fuser\u002Ftoken\u002FMS4wLjABAAAA-zO4FIkTaHs7RWfbEvMWSg5481TH8enpiYeOz5Z1r0U\u002F?source=tuwen_detail)\n\n**世界农化网中文网**报道：近日，中国农业科学院烟草研究所烟草病虫害绿色防控创新团队成功研发一种新型双金属人工水解酶，可高效降解细菌生物膜并杀死细菌，为细菌性病害绿色防控药剂的创制提供了全新设计策略。相关成果发表在国际顶级期刊《德国应用化学（Angewandte Chemie International Edition）》（IF=17.6），获选为当期封面文章，并被列为期刊热点论文（Hot Paper）。\n\n细菌生物膜是病原菌通过群体感应形成的胞外屏障，其结构完整性高度依赖于胞外多糖等大分子交织形成的骨架网络，可显著削弱防治药剂渗透与宿主免疫识别，是导致防治药剂防效骤降、田间病害反复暴发的核心诱因。\n\n针对制约农业细菌性病害防治的技术瓶颈，研究团队将高活性Ce4+引入金属有机框架，构建出具有双金属共定位活性中心的人工水解酶；通过密度泛函理论计算，首次阐明其区别于天然水解酶的独特催化路径。该酶具有良好的生物安全性和环境耐受性，可高效水解糖苷键，实现对细菌生物膜多糖骨架的靶向降解，生物膜清除率超80%，杀菌率超85%。\n\n![Image 1](https:\u002F\u002Fp3-sign.toutiaoimg.com\u002Ftos-cn-i-axegupay5k\u002Fcdccf90ebfd04a03bd2f35d88ecf8986~tplv-tt-origin-web:gif.jpeg?_iz=58558&from=article.pc_detail&lk3s=953192f4&x-expires=1786838058&x-signature=dKuFjAy4MNfETDD4afKqmWKTcqQ%3D)\n该成果突破传统杀菌剂依赖，首次将人工水解酶应用于生物膜的靶向清除，基于″解膜-杀菌″联动机制开辟了绿色防控新路径，对破解当前细菌性病害防治无特效药可用的产业困境具有重要现实意义。","中国农业科学院烟草所\u002F世界农化网 2026-08-06","2026-08-06T00:00:00Z","报道",10,false,86,{"impact":17,"substance":18,"depth":19,"authority":20,"freshness":21,"relevant":22,"comment":23},25,22,18,13,8,1,"国家级科研机构重大突破，登顶刊封面，数据详实，对农业细菌病害防控有重要价值。",[25],{"name":10,"url":6},[27,28,29,30,31,32],"中国农科院","绿色防控","烟草所","人工水解酶","细菌生物膜","Angewandte 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Journal）》上。\n\n病原细菌是引发植物病害的重要元凶，传统检测方法依赖大型仪器和专业实验室，流程复杂且耗时，难以满足田间快速筛查需求。同时样品中细菌含量较低，加上杂质干扰，给精准检测带来挑战。\n\n科研团队设计出一种无需外接动力设备的“指压式”检测芯片，只需轻轻一按，液体便会在芯片内流动，依次完成样品反应和检测过程。芯片将不同反应过程分隔在独立空间中，有效减少相互干扰，检测结果更加稳定可靠。同时，搭建特殊纳米识别界面的芯片，能够像“生物雷达”一样精准锁定目标细菌，一旦目标出现，迅速启动信号放大过程，输出清晰可见的荧光结果，实现极低浓度细菌的快速读取。","中国农科院烟草所 2026-08-24","2026-08-24T00:00:00Z",77,{"impact":19,"substance":82,"depth":83,"authority":84,"freshness":85,"relevant":22,"comment":86},20,16,14,9,"国家级科研机构发布的新型检测技术，对农业病害快速筛查有实际应用价值，信息具体且时效性好。",[88],{"name":78,"url":75},[27,29,90,91,92,93],"微流控芯片","病原细菌","检测","掌上芯片",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[],{"status":41,"locked":14,"version":42,"method":43,"evidence":97},{"candidates":98,"agricultural_evidence":48},[99,103],{"code":34,"score":47,"supported":48,"title":100,"abstract":101,"tags":102},[50],[50],[],{"code":54,"score":104,"supported":48,"title":105,"abstract":106,"tags":107},3,[],[28],[],[109,110],"中国农科院 微流控芯片 掌上芯片 病原细菌","中国农科院 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latifolia)是中国特有的禾本科水生植物,因长期与水稻伴生,具备合成高含量类黄酮的代谢通路。研究团队通过系统解析菰类黄酮合成关键调控基因的功能,成功将其在水稻胚乳中特异性表达,显著提升水稻籽粒中的类黄酮含量。该研究成果为水稻营养品质育种提供了新的基因资源和调控途径,通过分子育种手段可以培育类黄酮含量高的「功能水稻」新品种,助力居民膳食营养改善和稻米产业提质增效,展示了中国农科院在作物营养品质改良领域的原始创新能力和多学科协同攻关实力。","[人民日报头版头条]力度更大 “四个面向”为基础研究划重点（总书记的关切·落地的回响）\n\n7月10日，海南商业航天发射场，长征十号乙运载火箭首飞成功，我国运载火箭首次实现可控回收。中国航天一次次创造历史，离不开材料制备、流体动力、空间物理等方面的基础研究突破。","中国农业科学院 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width: 3px\\\"\\u003e\\u003csvg data-nest-level=\\\"11\\\" style=\\\"float: left; line-height: 0; vertical-align: top; width: 0\\\" viewBox=\\\"0 0 1 1\\\"\\u003e\\u003c\u002Fsvg\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003csection data-nest-level=\\\"7\\\" style=\\\"align-self: flex-end; box-sizing: border-box; display: inline-block; flex: 0 0 0%; height: auto; vertical-align: bottom; width: auto\\\"\\u003e\\u003csection data-nest-level=\\\"8\\\" style=\\\"-moz-transform: perspective(0px); -o-transform: perspective(0px); -webkit-transform: perspective(0px); box-sizing: border-box; transform: perspective(0px); transform-style: flat\\\"\\u003e\\u003csection data-nest-level=\\\"9\\\" style=\\\"-moz-transform: rotateX(180deg); -o-transform: rotateX(180deg); -webkit-transform: rotateX(180deg); box-sizing: border-box; margin: 0px; text-align: center; transform: rotateX(180deg)\\\"\\u003e\\u003csection 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normal\\\"\\u003e\\u003cspan data-nest-level=\\\"10\\\" leaf=\\\"\\\"\\u003e\\u003cbr\u002F\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fp\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003csection data-nest-level=\\\"5\\\"\\u003e\\u003cp data-nest-level=\\\"6\\\"\\u003e\\u003cspan data-pm-slice=\\\"0 0 []\\\"\\u003e\\u003cspan data-pm-slice=\\\"0 0 []\\\"\\u003e\\u003cspan data-pm-slice=\\\"0 0 []\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e近日，中国农业科学院\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e棉花研究所\\u003c\u002Fspan\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e棉花虫害防控与生物安全创新团队研究发现棉蚜通过DNA甲基化重编程，实现从解毒生存到建立种群的时序性适应策略。相关研究成果发表在\\u003cspan style=\\\"color: rgb(4, 102, 141); font-weight: bold\\\" textstyle=\\\"\\\"\\u003e《前沿研究杂志（Journal of Advanced Research）》\\u003c\u002Fspan\\u003e上。\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fp\\u003e\\u003c\u002Fsection\\u003e\\u003csection data-nest-level=\\\"5\\\" style=\\\"box-sizing: border-box; display: flex; flex-flow: row; justify-content: flex-start; margin: 0px\\\"\\u003e\\u003csection data-nest-level=\\\"6\\\" style=\\\"align-self: flex-end; box-sizing: border-box; display: inline-block; flex: 0 0 0%; height: auto; margin: 0px 4px 0px 0px; vertical-align: bottom; width: auto\\\"\\u003e\\u003csection data-nest-level=\\\"7\\\" style=\\\"-moz-transform: perspective(0px); -o-transform: perspective(0px); -webkit-transform: perspective(0px); box-sizing: border-box; transform: perspective(0px); transform-style: flat\\\"\\u003e\\u003csection data-nest-level=\\\"8\\\" style=\\\"-moz-transform: rotateX(180deg); -o-transform: rotateX(180deg); -webkit-transform: rotateX(180deg); box-sizing: border-box; text-align: center; transform: rotateX(180deg)\\\"\\u003e\\u003csection data-nest-level=\\\"9\\\" style=\\\"background-color: rgb(28, 136, 136); box-sizing: border-box; display: inline-block; height: 10px; overflow: hidden; vertical-align: top; width: 3px\\\"\\u003e\\u003csvg data-nest-level=\\\"10\\\" style=\\\"float: left; line-height: 0; vertical-align: top; width: 0\\\" viewBox=\\\"0 0 1 1\\\"\\u003e\\u003c\u002Fsvg\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003csection data-nest-level=\\\"6\\\" style=\\\"align-self: flex-end; box-sizing: border-box; display: inline-block; flex: 0 0 0%; height: auto; vertical-align: bottom; width: auto\\\"\\u003e\\u003csection data-nest-level=\\\"7\\\" style=\\\"-moz-transform: perspective(0px); -o-transform: perspective(0px); -webkit-transform: perspective(0px); box-sizing: border-box; transform: perspective(0px); transform-style: flat\\\"\\u003e\\u003csection data-nest-level=\\\"8\\\" style=\\\"-moz-transform: rotateX(180deg); -o-transform: rotateX(180deg); -webkit-transform: rotateX(180deg); box-sizing: border-box; margin: 0px; text-align: center; transform: rotateX(180deg)\\\"\\u003e\\u003csection data-nest-level=\\\"9\\\" style=\\\"background-color: rgb(28, 136, 136); box-sizing: border-box; display: inline-block; height: 16px; overflow: hidden; vertical-align: top; width: 3px\\\"\\u003e\\u003csvg data-nest-level=\\\"10\\\" style=\\\"float: left; line-height: 0; vertical-align: top; width: 0\\\" viewBox=\\\"0 0 1 1\\\"\\u003e\\u003c\u002Fsvg\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003csection data-nest-level=\\\"6\\\" style=\\\"align-self: flex-end; border-bottom: 1px solid rgb(28, 136, 136); border-bottom-right-radius: 0px; box-sizing: border-box; display: inline-block; flex: 0 0 auto; height: auto; margin: 0px; padding: 4px 4px 4px 11px; vertical-align: bottom; width: 100px\\\"\\u003e\\u003csection data-nest-level=\\\"7\\\" style=\\\"box-sizing: border-box; text-align: justify\\\"\\u003e\\u003cp data-nest-level=\\\"8\\\" style=\\\"box-sizing: border-box; margin: 0px; padding: 0px; white-space: normal\\\"\\u003e\\u003cspan data-nest-level=\\\"9\\\" leaf=\\\"\\\"\\u003e\\u003cbr\u002F\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fp\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003c\u002Fsection\\u003e\\u003csection nodeleaf=\\\"\\\" style=\\\"margin-bottom: 8px; margin-top: 8px; text-align: center\\\"\\u003e\\u003c!--IMG_0--\\u003e\\u003c\u002Fsection\\u003e\\u003cp data-pm-slice=\\\"0 0 []\\\" style=\\\"margin-bottom: 8px\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e棉蚜是世界性重大害虫，寄主范围广泛，并在长期进化中形成了寄主专化型现象，不同专化型对其寄主表现出高度适应性。棉蚜如何跨越屏障完成新寄主适应的分子机制尚不清楚。\\u003c\u002Fspan\\u003e\\u003c!--NO_AD_0--\\u003e\\u003c!--EOP_0--\\u003e\\u003c\u002Fp\\u003e\\u003c!--PARAGRAPH_0--\\u003e\\u003cp style=\\\"margin-bottom: 8px\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e该研究构建了棉蚜寄主转换的动态表观遗传图谱，发现棉蚜在适应新寄主过程中，全基因组DNA甲基化水平呈先升后降趋势，核心调控因子发挥表观遗传开关作用。进一步研究发现，该核心调控因子在早期优先激活棉蚜解毒基因，帮助棉蚜克服新寄主的化学防御，随后激活繁殖基因保障棉蚜种群建立。该成果为开发棉蚜新型绿色防控技术与可持续害虫管理提供了理论支撑。\\u003c\u002Fspan\\u003e\\u003c!--NO_AD_1--\\u003e\\u003c!--EOP_1--\\u003e\\u003c\u002Fp\\u003e\\u003c!--PARAGRAPH_1--\\u003e\\u003cp style=\\\"margin-bottom: 8px\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6\\\"\\u003e该研究得到河南省自然科学基金、国家重点研发计划等项目支持。\\u003c\u002Fspan\\u003e\\u003c\u002Fp\\u003e\\u003csection class=\\\"js_darkmode__9\\\" data-nest-level=\\\"3\\\" data-pm-slice=\\\"1 3 []\\\" data-style=\\\"margin-right: 8px; margin-bottom: 8px; margin-left: 8px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, \\u0026#34;Helvetica Neue\\u0026#34;, \\u0026#34;PingFang SC\\u0026#34;, \\u0026#34;Hiragino Sans GB\\u0026#34;, \\u0026#34;Microsoft YaHei UI\\u0026#34;, \\u0026#34;Microsoft YaHei\\u0026#34;, Arial, sans-serif; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); text-align: center; visibility: visible;\\\" nodeleaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: 0.544px; margin: 0px; max-width: 100%; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-indent: 0px; text-transform: none; visibility: visible; white-space: normal; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e\\u003cimg alt=\\\"图片\\\" class=\\\"__bg_gif rich_pages wxw-img js_darkmode__10\\\" data-aistatus=\\\"1\\\" data-fileid=\\\"100014628\\\" data-imgfileid=\\\"100039142\\\" data-ratio=\\\"0.36923076923076925\\\" data-src=\\\"https:\u002F\u002Finews.gtimg.com\u002Fom_bt\u002FGgXXkAjkV5hA2SwBSyHUj5Xi2B3qIU84LhhHRRNeQFHH4AA\u002F0\\\" data-type=\\\"gif\\\" data-w=\\\"65\\\" src=\\\"https:\u002F\u002Finews.gtimg.com\u002Fom_bt\u002FGgXXkAjkV5hA2SwBSyHUj5Xi2B3qIU84LhhHRRNeQFHH4AA\u002F0\\\" style=\\\"-webkit-tap-highlight-color: transparent; background-size: 16px !important; border-radius: 8px; border-style: none; box-sizing: border-box !important; color: rgb(34, 34, 34); height: auto; letter-spacing: 0.544px; line-height: 0px; margin: 0px; max-width: 100%; outline: 0px; overflow-wrap: break-word !important; padding: 0px; vertical-align: middle; visibility: visible !important; width: 65px !important\\\" width=\\\"65px\\\" data-aigc-mark=\\\"0\\\"\u002F\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fsection\\u003e\\u003csection class=\\\"js_darkmode__11\\\" data-nest-level=\\\"3\\\" data-pm-slice=\\\"0 0 []\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: 0.544px; margin: 0px; max-width: 100%; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-indent: 0px; text-transform: none; visibility: visible; white-space: normal; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan class=\\\"js_darkmode__12\\\" data-nest-level=\\\"4\\\" leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e来源\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003cspan class=\\\"js_darkmode__13\\\" data-nest-level=\\\"4\\\" leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e丨棉花所\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003cspan data-nest-level=\\\"4\\\" data-pm-slice=\\\"0 0 []\\\"\\u003e\\u003cspan data-nest-level=\\\"5\\\" leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cbr\u002F\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fsection\\u003e\\u003csection class=\\\"js_darkmode__11\\\" data-nest-level=\\\"3\\\" data-pm-slice=\\\"0 0 []\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: 0.544px; margin: 0px; max-width: 100%; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-indent: 0px; text-transform: none; visibility: visible; white-space: normal; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e作者丨\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003cspan data-pm-slice=\\\"0 0 []\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e高雪珂\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003c\u002Fsection\\u003e\\u003csection class=\\\"js_darkmode__11\\\" data-nest-level=\\\"3\\\" data-pm-slice=\\\"0 0 []\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: 400; letter-spacing: 0.544px; margin: 0px; max-width: 100%; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-indent: 0px; text-transform: none; visibility: visible; white-space: normal; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan leaf=\\\"\\\" style=\\\"-webkit-tap-highlight-color: transparent; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); box-sizing: border-box !important; color: rgba(0, 0, 0, 0.9); flex-direction: column; font-size: 17px; font-style: normal; font-variant-caps: normal; font-variant-ligatures: normal; font-weight: normal; letter-spacing: 0.034em; line-height: 1.6; margin: 0px; max-width: none !important; orphans: 2; outline: 0px; overflow-wrap: break-word !important; padding: 0px; text-align: center; text-decoration-color: initial; text-decoration-style: initial; text-decoration-thickness: initial; text-indent: 0px; text-transform: none; visibility: visible; widows: 2; word-spacing: 0px\\\"\\u003e\\u003cspan style=\\\"color: rgb(136, 136, 136); font-size: 15px\\\" textstyle=\\\"\\\"\\u003e通讯员丨梁冰\\u003c\u002Fspan\\u003e\\u003c\u002Fspan\\u003e\\u003cspan data-pm-slice=\\\"1 1 [\\u0026#34;para\\u0026#34;,{\\u0026#34;tagName\\u0026#34;:\\u0026#34;section\\u0026#34;,\\u0026#34;attributes\\u0026#34;:{\\u0026#34;style\\u0026#34;:\\u0026#34;box-sizing: border-box;font-style: normal;font-weight: 400;text-align: justify;font-size: 16px;colo\n[…全文已截断…]","中国农业科学院棉花研究所 2026-08-03","2026-08-03T00:00:00Z",85,{"impact":18,"substance":18,"depth":19,"authority":84,"freshness":85,"relevant":22,"comment":181},"国家级科研机构发布棉蚜寄主适应机制新发现，具科研价值，但属细分领域进展，影响范围有限。",[183],{"name":177,"url":174},[27,28,185,186,187],"棉花所","棉蚜","DNA甲基化",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[],{"status":41,"locked":14,"version":42,"method":43,"evidence":191},{"candidates":192,"agricultural_evidence":48},[193,198,202],{"code":34,"score":47,"supported":48,"title":194,"abstract":196,"tags":197},[195],"棉花",[195],[],{"code":54,"score":55,"supported":48,"title":199,"abstract":200,"tags":201},[],[28],[28],{"code":60,"score":22,"supported":14,"title":203,"abstract":204,"tags":205},[],[],[28],[207,208],"中国农科院 绿色防控 DNA甲基化 棉花所","中国农科院 绿色防控","中国农科院绿色防控DNA甲基化棉花所-191","2026-08-04T01:15:44.465753Z",{"id":212,"title":213,"url":214,"summary":215,"summary_zh":8,"content":216,"source_name":217,"source_url":8,"published_at":218,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":219,"score_detail":220,"sources":222,"tags":224,"primary_topic":228,"secondary_topics":229,"classification":230,"search_phrases":242,"slug":245,"view_count":112,"doi":8,"paper":8,"created_at":246},4766,"棉花关键技术集成助力高温逆境下产量品质效益三丰收","https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?cat=T&id=572667","中国农业科学院西部农业研究中心在昌吉州老龙河综合试验基地举办棉花优质高产关键技术集成示范观摩会。千亩示范方实测籽棉平均亩产601.4公斤,集成中棉113优系、中新棉1号、3号等优质多抗新品种,以及高光效群体调控、智慧棉田管理、绿色病虫害防控等成套技术,节药15%以上、人工成本降低30%以上。","科学网—\n\n## [![Image 1: 科学网](https:\u002F\u002Fwap.sciencenet.cn\u002Fstatic\u002Fimage\u002Fcommon\u002Flogo.png)](https:\u002F\u002Fwap.sciencenet.cn\u002F \"科学网\")\n\n*   [要闻](https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?type=news&cat=yaowen&mobile=1)\n*   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2026-10-10","2026-10-10T00:00:00Z",73,{"impact":18,"substance":19,"depth":84,"authority":20,"freshness":70,"relevant":22,"comment":221},"报道中国农科院棉花高温逆境关键技术集成取得产量品质效益三丰收，属细分领域实质进展，但时效稍旧、信息增量有限，可入精选备选。",[223],{"name":217,"url":214},[225,27,195,226,227],"智慧农业","技术集成","高温逆境",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[],{"status":41,"locked":14,"version":42,"method":43,"evidence":231},{"candidates":232,"agricultural_evidence":48},[233,237],{"code":34,"score":125,"supported":48,"title":234,"abstract":235,"tags":236},[195],[195],[195],{"code":238,"score":22,"supported":14,"title":239,"abstract":240,"tags":241},"I1",[],[],[225],[243,244],"中国农科院 棉花 高温逆境","棉花 关键技术集成 产量品质","中国农科院棉花高温逆境-4766","2026-10-13T00:08:35.350655Z",{"id":248,"title":249,"url":250,"summary":251,"summary_zh":8,"content":8,"source_name":252,"source_url":8,"published_at":253,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":15,"score_detail":254,"sources":256,"tags":258,"primary_topic":262,"secondary_topics":263,"classification":269,"search_phrases":284,"slug":287,"view_count":104,"doi":8,"paper":8,"created_at":288},2842,"中国农科院烟草所双金属人工水解酶开辟细菌性病害绿色防控新路径登Angewandte Chemie","https:\u002F\u002Fnews.qq.com\u002Frain\u002Fa\u002F20260917A03VJ100","近日,中国农业科学院烟草研究所烟草病虫害绿色防控创新团队成功研发一种新型双金属人工水解酶,可高效降解细菌生物膜并杀灭病原菌。团队将高活性铈引入金属有机框架,构建双金属人工水解酶,阐明其区别于天然酶的独特催化路径。该酶具有良好的生物安全性与环境稳定性,可精准切断细菌生物膜多糖骨架的化学键,瓦解细菌防护膜,清除率超80%,杀菌率超85%。该成果首次将人工水解酶应用于细菌生物膜靶向清除,为农作物绿色防控开辟新路径。","腾讯新闻 \u002F 中国农业科学院烟草研究所","2026-09-17T00:00:00Z",{"impact":18,"substance":18,"depth":19,"authority":84,"freshness":13,"relevant":22,"comment":255},"国家级科研机构在核心期刊发表的双金属人工水解酶成果，首次实现细菌生物膜靶向清除，数据扎实、时效性强，具备进入每日精选的价值。",[257],{"name":252,"url":250},[28,259,260,50,261],"农业科技","人工酶","生物膜",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[264],{"code":54,"slug":265,"name":266,"path":267,"parent_code":268},"crop-protection","农药与绿色防控","\u002Ftopic\u002Finputs-equipment\u002Fcrop-protection","F",{"status":41,"locked":14,"version":42,"method":43,"evidence":270},{"candidates":271,"agricultural_evidence":48},[272,276,280],{"code":34,"score":125,"supported":48,"title":273,"abstract":274,"tags":275},[50],[50],[50],{"code":54,"score":125,"supported":48,"title":277,"abstract":278,"tags":279},[28],[28],[28],{"code":60,"score":22,"supported":14,"title":281,"abstract":282,"tags":283},[],[],[28],[285,286],"农业科技 绿色防控 人工酶 生物膜","农业科技 绿色防控","农业科技绿色防控人工酶生物膜-2842","2026-09-18T00:03:28.675103Z",{"id":290,"title":291,"url":292,"summary":293,"summary_zh":8,"content":294,"source_name":295,"source_url":8,"published_at":296,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":297,"score_detail":298,"sources":300,"tags":302,"primary_topic":305,"secondary_topics":306,"classification":308,"search_phrases":323,"slug":326,"view_count":55,"doi":8,"paper":8,"created_at":327},1556,"中国农业科学院烟草所：双金属人工酶开辟细菌性病害绿色防控新路径（Angewandte Chemie）","https:\u002F\u002Fwww.caas.cn\u002Fxwzx\u002Fkyhd\u002F59452b198605475b991f2f29d9ea6f61.htm","近日，中国农业科学院烟草研究所烟草病虫害绿色防控创新团队成功研发一种新型双金属人工水解酶，可高效降解细菌生物膜并杀灭病原菌。该酶将高活性铈引入金属有机框架，具有良好的生物安全性与环境稳定性，清除率超 80%、杀菌率超 85%。该成果突破传统杀菌剂依赖，首次将人工水解酶应用于细菌生物膜靶向清除，打破了细菌性病害缺乏特效药的产业困境，为农作物绿色防控开辟新路径。相关成果发表在《德国应用化学》（Angewandte Chemie International Edition）上。","[English](https:\u002F\u002Fwww.caas.cn\u002Fen)[邮箱](https:\u002F\u002Fmail.caas.cn\u002F)[数字农科院](https:\u002F\u002Fi.caas.cn\u002F)[](https:\u002F\u002Fwww.caas.cn\u002Fcms\u002Fweb\u002Fsearch\u002Findex.jsp?siteID=cdb01dceb46e48488945d4465e90f221&aba=)\n\n官方微信 \n\n![Image 2](https:\u002F\u002Fwww.caas.cn\u002Fimages\u002F2023-01\u002F020ac4d3d8b6451782a8702c72604336.jpg)农科专家在线微信公众号\n\n![Image 3](https:\u002F\u002Fwww.caas.cn\u002Fimages\u002F2023-01\u002Fbf6579e4651e437db31a22cd2249b319.jpg)中国农科院微信公众号\n\n[![Image 4](https:\u002F\u002Fwww.caas.cn\u002Fstatic2022\u002Fimages\u002Fmenu_logo.png)](https:\u002F\u002Fwww.caas.cn\u002Findex.htm)\n\n*   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Edition）》上。\n\n细菌生物膜是病原菌通过群体感应分泌形成的“保护壳”，其主要骨架由糖类物质交织而成，可显著削弱药剂渗透与免疫清除，导致田间防治效果大幅降低，是病害反复暴发的核心诱因。\n\n针对制约农业细菌性病害防治的技术瓶颈，研究团队将高活性铈引入金属有机框架，构建双金属人工水解酶，并阐明其区别于天然酶的独特催化路径。该酶具有良好的生物安全性与环境稳定性，可精准切断细菌生物膜多糖骨架的化学键，瓦解细菌防护膜，清除率超80%，杀菌率超85%。该成果突破传统杀菌剂依赖，首次将人工水解酶应用于细菌生物膜靶向清除，打破了细菌性病害缺乏特效药的产业困境，为农作物绿色防控开辟新路径。\n\n该研究得到国家自然科学基金和山东省自然科学基金等项目支持。（通讯员 李晓娟）\n\n论文链接：https:\u002F\u002Fdoi.org\u002F10.1002\u002Fanie.9481237\n\n![Image 8: 001.png](https:\u002F\u002Fwww.caas.cn\u002Fimages\u002F2026-09\u002Fe45c5f97ad2e4c81847a32cfe5fd39bc.png)\n\n打印本页\n\n关闭本页\n\n[院网信息发布与管理](https:\u002F\u002Fwww.caas.cn\u002Fywxxfbygl\u002Findex.htm)[最新动态](https:\u002F\u002Fwww.caas.cn\u002Fywxxfbygl\u002Findex.htm)\n\n*   [第7期“农科讲坛”举办 以农业农村现代化推动实现中国式现代化](https:\u002F\u002Fwww.caas.cn\u002Fxwzx\u002Fnkyw\u002F1c78565c9c5648c5b6f3e70d035deb07.htm)2026-08-31  \n*   [西梅浆加工色泽劣变规律被揭示](https:\u002F\u002Fwww.caas.cn\u002Fxwzx\u002Fkyhd\u002F958676b943cb4e229d3f617ba4f35e75.htm)2026-08-31  \n*   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京公网安备11010802048565号](http:\u002F\u002Fwww.beian.gov.cn\u002Fportal\u002FregisterSystemInfo?recordcode=11010802048565)","中国农业科学院·科研进展","2026-09-03T00:00:00Z",83,{"impact":82,"substance":18,"depth":19,"authority":124,"freshness":21,"relevant":22,"comment":299},"中国农科院烟草所开发双金属人工酶，为细菌性病害绿色防控提供新路径，发表于Angewandte Chemie，具有较高科研价值和行业影响。",[301],{"name":295,"url":292},[28,260,303,50,304],"细菌病害","生物防治",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[307],{"code":54,"slug":265,"name":266,"path":267,"parent_code":268},{"status":41,"locked":14,"version":42,"method":43,"evidence":309},{"candidates":310,"agricultural_evidence":48},[311,315,319],{"code":54,"score":20,"supported":48,"title":312,"abstract":313,"tags":314},[28],[28],[304,28],{"code":34,"score":125,"supported":48,"title":316,"abstract":317,"tags":318},[50],[50],[50],{"code":60,"score":22,"supported":14,"title":320,"abstract":321,"tags":322},[],[],[28],[324,325],"生物防治 细菌病害 绿色防控 人工酶","生物防治 细菌病害","生物防治细菌病害绿色防控人工酶-1556","2026-09-04T00:05:31.812843Z"]