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副猪格拉瑟菌","猪三联灭活疫苗新兽药-5342","2026-10-20T02:47:43.773043Z",{"id":200,"title":201,"url":202,"summary":203,"summary_zh":8,"content":204,"source_name":205,"source_url":8,"published_at":206,"category":75,"cover_url":8,"hotness":13,"is_selected":14,"score":207,"score_detail":208,"sources":210,"tags":212,"primary_topic":218,"secondary_topics":219,"classification":220,"search_phrases":227,"slug":230,"view_count":153,"doi":8,"paper":8,"created_at":231},5338,"中国农科院哈尔滨兽医所揭示非洲猪瘟病毒与宿主攻防机制 Advanced Science","https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572939.shtm","中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装以及病毒如何反击的分子机制,相关研究成果发表在 Advanced Science 上。研究通过体内外实验发现,这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白,抑制衣壳组装;作为逃逸策略,非洲猪瘟病毒通过分子模拟劫持细胞自噬系统反过来降解该受体。该研究为开发新型抗病毒制剂提供了新靶标,论文 DOI: 10.1002\u002Fadvs.77741。","[![Image 1: 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[人才](https:\u002F\u002Ftalent.sciencenet.cn\u002F) | [会议](https:\u002F\u002Fmeeting.sciencenet.cn\u002F) | [基金·项目](https:\u002F\u002Ffund.sciencenet.cn\u002F) | [论文](https:\u002F\u002Fpaper.sciencenet.cn\u002F) | [绘图](https:\u002F\u002Fvisual-web.sciencenet.cn\u002F) | [视频·直播](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog.php?mod=video) | [小柯机器人](https:\u002F\u002Fpaper.sciencenet.cn\u002FAInews) | [医学科普](https:\u002F\u002Fyxkp.sciencenet.cn\u002F)\n\n作者：李晨,邓彦莉 来源：中国科学报 发布时间：2026\u002F10\u002F15 11:58:32 选择字号：小 中 大 研究揭示非洲猪瘟病毒与宿主“攻防”机制 近日，中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装，以及病毒如何“反击”的分子机制。相关研究成果发表在《先进科学》（_**Advanced Science**_）上。 内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。 该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。 该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。 相关论文信息：https:\u002F\u002Fdoi.org\u002F10.1002\u002Fadvs.77741 版权声明：凡本网注明“来源：中国科学报、科学网、科学新闻杂志”的所有作品，网站转载，请在正文上方注明来源和作者，且不得对内容作实质性改动；微信公众号、头条号等新媒体平台，转载请联系授权。邮箱：shouquan@stimes.cn。\n\n打印 发E-mail给：\n\n以下评论只代表网友个人观点，不代表科学网观点。\n\n[![Image 2](https:\u002F\u002Fnews.sciencenet.cn\u002Fimages\u002Fnewcomm.gif)](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtml\u002Fcomment.aspx?id=572939)\n\n相关新闻 相关论文\n*   1\n*   [微型机器人靶向心脏感染病灶精准送药](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572918.shtm)\n\n*   2\n*   [这个打破常识的发现因何而来](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572917.shtm)\n\n*   3\n*   [科学家捕获最远快速射电暴](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572916.shtm)\n\n*   4\n*   [罗先刚院士：科技创新下一程，不是“接力赛”！](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572915.shtm)\n\n*   5\n*   [研究显示：孕期慢性压力会改变胎盘影响胎儿大脑发育](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572914.shtm)\n\n*   6\n*   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[更多>>](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog.php?mod=recommend)\n\n* * *\n\n近日，中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装，以及病毒如何“反击”的分子机制。相关研究成果发表在《先进科学》（_**Advanced Science**_）上。\n\n内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。\n\n该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。\n\n该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。\n\n相关论文信息：https:\u002F\u002Fdoi.org\u002F10.1002\u002Fadvs.77741","中国农业科学院哈尔滨兽医研究所 2026-10-15","2026-10-15T00:00:00Z",83,{"impact":17,"substance":17,"depth":78,"authority":19,"freshness":66,"relevant":22,"comment":209},"国家级科研机构在顶刊发表非洲猪瘟攻防机制新发现，为新型抗病毒制剂提供靶标，专业增量明确，但属基础研究、时效稍弱，可入精选。",[211],{"name":205,"url":202},[213,214,215,216,217],"动物疫病防控","非洲猪瘟","内质网自噬","病毒与宿主互作","抗病毒靶标",{"code":33,"slug":34,"name":35,"path":36,"parent_code":37},[],{"status":40,"locked":14,"version":41,"method":42,"evidence":221},{"candidates":222,"agricultural_evidence":47},[223],{"code":33,"score":164,"supported":47,"title":224,"abstract":225,"tags":226},[214],[214],[213,214],[228,229],"哈兽研 非洲猪瘟 衣壳组装","非洲猪瘟病毒 内质网自噬","哈兽研非洲猪瘟衣壳组装-5338","2026-10-20T02:47:43.543999Z",{"id":233,"title":234,"url":235,"summary":236,"summary_zh":8,"content":237,"source_name":238,"source_url":8,"published_at":8,"category":75,"cover_url":8,"hotness":13,"is_selected":47,"score":239,"score_detail":240,"sources":245,"tags":247,"primary_topic":252,"secondary_topics":253,"classification":254,"search_phrases":270,"slug":273,"view_count":22,"doi":8,"paper":8,"created_at":274},5214,"山东省农科院首创猪链球菌-副猪格拉瑟菌-猪圆环病毒2型三联灭活疫苗获国家新兽药","http:\u002F\u002Fwww.saas.ac.cn\u002Farticles\u002Fch10721\u002F202610\u002F3363f4c1-7d36-4c1b-a996-f5ec3bab1b34.shtml","山东省农业科学院畜牧兽医所动物疫病防控创新团队研发的猪链球菌、副猪格拉瑟菌、猪圆环病毒2型三联灭活疫苗获农业农村部批准国家新兽药注册证书(【2026】新兽药证字109号),实现\"一针防三病\"。","近日，农业农村部发布第1062号公告，畜牧兽医所动物疫病防控创新团队研发的“猪链球菌、副猪格拉瑟菌、猪圆环病毒2型三联灭活疫苗(2型QH株+5型LZ株+Cap蛋白)”获农业农村部批准，取得国家新兽药注册证书（【2026】新兽药证字109号），标志着我院在猪多联多价疫苗研发领域实现重要突破。\n\n临床上，猪圆环病毒病常诱发猪链球菌、副猪格拉瑟菌的继发感染，导致猪群死淘率升高，已成为制约养猪业健康发展的突出痛点。畜牧兽医研究所动物疫病防控创新团队针对生猪病毒和细菌混合感染高发、免疫程序繁杂等产业难题持续攻关，突破细菌高密度精准发酵、蛋白高效表达纯化、多抗原协同兼容等关键技术瓶颈，自主创制出国内外首个猪链球菌、副猪格拉瑟菌、猪圆环病毒2型三联灭活疫苗，实现“一针防三病”，能显著减少免疫频次，降低养殖防疫成本和猪群应激。目前，该产品已转让三家大型动保企业，正式进入产业化落地的重要阶段。产品量产落地后，将补齐生猪混合感染疫病高效防控短板，助推生猪养殖业稳产提质、健康可持续发展。（撰稿：于江     核稿：朱小玲）","山东省农业科学院(2026-10)",88,{"impact":241,"substance":242,"depth":243,"authority":163,"freshness":21,"relevant":22,"comment":244},26,23,16,"国内首个猪用三联灭活疫苗获国家新兽药证书并进入产业化，属产业级技术突破，信息增量与信源权威度俱佳，值得进入每日精选。",[246],{"name":238,"url":235},[170,248,249,250,251],"生猪养殖","疫病防控","兽药疫苗","科研成果",{"code":33,"slug":34,"name":35,"path":36,"parent_code":37},[],{"status":40,"locked":14,"version":41,"method":42,"evidence":255},{"candidates":256,"agricultural_evidence":47},[257,261,265],{"code":33,"score":19,"supported":47,"title":258,"abstract":259,"tags":260},[49],[182,49],[170],{"code":37,"score":54,"supported":47,"title":262,"abstract":263,"tags":264},[],[186],[],{"code":266,"score":22,"supported":14,"title":267,"abstract":268,"tags":269},"C1",[],[],[248],[271,272],"山东省农科院 猪链球菌 三联灭活疫苗","猪圆环病毒2型 新兽药 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Science）》上。\n\n内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。\n\n该研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。（通讯员 邓彦莉）","中国农业科学院哈尔滨兽医所(2026-10-12)","2026-10-12T00:00:00Z",{"impact":17,"substance":17,"depth":78,"authority":19,"freshness":66,"relevant":22,"comment":284},"国家级科研机构在非洲猪瘟基础研究上取得新机制发现，专业增量明确，对生猪疫病防控有潜在价值，值得进入每日精选。",[286],{"name":281,"url":278},[213,214,248,288,289],"病毒学","抗病毒制剂",{"code":33,"slug":34,"name":35,"path":36,"parent_code":37},[],{"status":40,"locked":14,"version":41,"method":42,"evidence":293},{"candidates":294,"agricultural_evidence":47},[295,299],{"code":33,"score":164,"supported":47,"title":296,"abstract":297,"tags":298},[214],[214],[213,214],{"code":266,"score":22,"supported":14,"title":300,"abstract":301,"tags":302},[],[],[248],[304,305],"哈尔滨兽医所 非洲猪瘟 衣壳组装","非洲猪瘟 内质网自噬 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