[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"item-560":3,"related-560":54},{"id":4,"title":5,"url":6,"summary":7,"summary_zh":8,"content":9,"source_name":10,"source_url":8,"published_at":11,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":15,"score_detail":16,"sources":23,"tags":25,"primary_topic":30,"secondary_topics":36,"classification":37,"search_phrases":49,"slug":52,"view_count":21,"doi":8,"paper":8,"created_at":53},560,"JIA 优先上线:中国农科院哈兽研基础免疫团队揭示 ASFV pA151R 抑制应激颗粒形成的关键机制","https:\u002F\u002Fbbs.sciencenet.cn\u002Fblog-3618084-1547906.html","哈兽研翁长江、黄丽团队在《Journal of Integrative Agriculture》在线发表论文,揭示非洲猪瘟病毒 pA151R 通过抑制 NXT1 启动子活性阻断 mRNA 核输出,进而抑制应激颗粒(SGs)形成与宿主蛋白合成的分子机制。A151R 基因缺失重组病毒复制能力降低,对 SGs 形成和天然免疫的抑制作用减弱,为开发抗 ASFV 药物和疫苗提供潜在靶点。",null,"非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）引起的一种高度致死性动物疫病，严重威胁全球养猪产业健康发展。应激颗粒（SGs）是应激诱导哺乳动物细胞形成的一种无膜聚集体，通过隔离病毒组分并调控抗病毒信号通路来抑制病毒复制。此前研究报道ASFV感染抑制SGs的形成，但参与调控SGs形成的病毒蛋白及其潜在分子机制仍不清楚。\n\n近期，中国农业科学院哈尔滨兽医研究所 翁长江研究员 和 黄丽研究员 团队 完成的题为“**African swine fever virus pA151R inhibits stress granule formation and host protein synthesis by disrupting mRNA nuclear export**”的研究 在**_Journal of Integrative A_****_gricultur_****_e（《农业科学学报_（英文）》，JIA）**优先在线发表。\n\n**本研究揭示了ASFV pA151R通过抑制NXT1启动子活性阻断mRNA核输出，进而抑制SGs形成与宿主蛋白合成的分子机制。A151R基因缺失显著减弱ASFV对SGs形成与宿主天然免疫的抑制作用，为阐明ASFV免疫逃逸机制及开发抗病毒药物提供了重要依据。**\n\n主要发现：\n\n**锁定新靶标：****ASFV pA151R抑制SGs形成**\n\n研究团队通过筛选鉴定发现，ASFV pA151R显著抑制eIF2α依赖与非依赖途径诱导的SGs形成。通过cNLS mapper预测，研究团队发现pA151R存在一个核定位信号（NLS）。删除该NLS显著减弱pA151R对SGs形成的抑制作用。\n\n![Image 1: 11.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140421fnrattn33z55fwbt.png)\n\n图1 ASFV pA151R抑制SGs形成依赖其NLS基序\n\n**揭示新机制：****ASFV pA151R调控mRNA核质运输**\n\n由于SGs形成依赖胞质中的mRNA形成核心骨架，因此研究团队通过原位杂交实验发现，pA151R能够导致poly(A)+ mRNA滞留于细胞核。进一步研究表明，pA151R通过抑制NXT1启动子活性下调其表达，进而阻碍mRNA出核，抑制SGs的形成与宿主蛋白合成。\n\n![Image 2: 12.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140426u9ciklizrzwh44xa.png)\n\n图2 ASFV pA151R抑制mRNA核质运输\n\n**验证复制相关基因功能：****A151R是ASFV的复制相关基因****与免疫抑制基因**\n\n为在病毒水平验证pA151R的生物学功能，研究团队基于ASFV Pig\u002FHLJ\u002F18毒株成功构建了A151R基因缺失重组病毒（ASFV-ΔA151R）。与野生型病毒相比，ASFV-ΔA151R的复制能力降低，并且对SGs形成与天然免疫的抑制作用减弱。\n\n![Image 3: 13.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140431kjggi5vj8g9jystv.png)\n\n图3 ASFV-△A151R的复制能力较低，对SGs形成的抑制作用减弱\n\n本研究发现ASFV pA151R是抑制SGs形成与宿主蛋白合成的关键因子，并阐明了pA151R通过限制mRNA核质运输和调节宿主蛋白合成抑制SGs形成，从而为病毒复制和免疫逃避创造有利环境的分子基础。研究结果不仅揭示了A151R作为复制相关基因在病毒免疫逃逸过程中的新功能，而且为开发抗ASFV药物和疫苗提供了潜在的靶点。\n\n中国农业科学院哈尔滨兽医研究所 博士研究生董思琦 为论文第一作者，翁长江研究员 与 黄丽研究员 为共同通讯作者。本研究得到了国家自然科学基金（32322081）等项目的资助。\n\nCite the article:Siqi Dong, Tingting Li, Longfei Han, Xiaoping He, Xiaohong Liu, Hanyu Wu, Changjiang Weng, Li Huang. 2026. African swine fever virus pA151R inhibits stress granule formation and host protein synthesis by disrupting mRNA nuclear export. Journal of Integrative Agriculture, Doi:10.1016\u002Fj.jia.2026.06.008\n\n[https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jia.2026.06.008](https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jia.2026.06.008)\n\n_Journal of Integrative Agriculture_（《农 业科学学报（英文）》, JIA）由中华人民共和国农业农村部主管，中国农业科学院与中国农学会主办，中国农业科学院农业信息研究所承办。综合性英文学术期刊，月刊。创刊于2002年，现任主编为中国科学院院士陈化兰。JIA主要栏目有作物科学、园艺、植物保护、动物科学、动物医学、农业生态环境、食品科学、农业经济与管理等。刊稿类型有综述、研究论文、简报以及评述等。全部论文在Elsevier-ScienceDirect (SD) 平台OA出版。最新SCI影响因子5.7，位于SCI-JCR农业综合学科Q1区。中国科学院分区农林科学1区。2016年以来先后获得中国科协等部委 “提升计划”“登峰计划”“卓越计划”项目支持。\n\n转载本文请联系原作者获取授权，同时请注明本文来自王宁科学网博客。\n\n链接地址： [https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547906.html](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547906.html)\n\n上一篇：[JIA封面文章 | 扬州大学兽医学院李向东教授团队系统揭示全球类NADC34猪繁殖与呼吸综合征病毒的重组演化动态](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547887.html)\n\n下一篇：[JIA｜中国农业大学水稻研究中心朱作峰团队揭示了非洲栽培稻进化过程中护颖变长的遗传控制](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547959.html)\n\n[欢迎参加科学网十佳博文评选活动！](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-45-1520553.html)\n\n主办单位： [![Image 4](https:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202606\u002F03\u002F170346g6h6jzlddzxnvgk1.jpg)](https:\u002F\u002Fwww.sciencenet.cn\u002F)支持单位：[![Image 5](https:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202606\u002F04\u002F150033i1jb7dpbv12pbsbs.jpg)](https:\u002F\u002Fais.cn\u002Fu\u002FQnia6z)","科学网博客 2026-08-13 中国农业科学院哈尔滨兽医研究所","2026-08-13T00:00:00Z","报道",10,false,84,{"impact":17,"substance":17,"depth":18,"authority":19,"freshness":20,"relevant":21,"comment":22},22,18,14,8,1,"揭示ASFV免疫逃逸新机制，对非洲猪瘟防控有重要科学价值，但属细分领域进展，影响范围有限。",[24],{"name":10,"url":6},[26,27,28,29],"中国农科院","非洲猪瘟","应激颗粒","JIA",{"code":31,"slug":32,"name":33,"path":34,"parent_code":35},"C5","animal-health","疫病防控与兽药","\u002Ftopic\u002Flivestock\u002Fanimal-health","C",[],{"status":38,"locked":14,"version":39,"method":40,"evidence":41},"classified","2026-10-22.2","rules",{"candidates":42,"agricultural_evidence":45},[43],{"code":31,"score":44,"supported":45,"title":46,"abstract":47,"tags":48},4,true,[],[27],[27],[50,51],"中国农科院 应激颗粒 非洲猪瘟 JIA","中国农科院 应激颗粒","中国农科院应激颗粒非洲猪瘟JIA-560","2026-08-15T23:54:32.189393Z",{"total":55,"page":21,"page_size":55,"items":56},6,[57,92,127,157,203,255],{"id":58,"title":59,"url":60,"summary":61,"summary_zh":8,"content":62,"source_name":63,"source_url":8,"published_at":64,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":65,"score_detail":66,"sources":69,"tags":71,"primary_topic":76,"secondary_topics":77,"classification":78,"search_phrases":86,"slug":89,"view_count":90,"doi":8,"paper":8,"created_at":91},5338,"中国农科院哈尔滨兽医所揭示非洲猪瘟病毒与宿主攻防机制 Advanced Science","https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572939.shtm","中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装以及病毒如何反击的分子机制,相关研究成果发表在 Advanced Science 上。研究通过体内外实验发现,这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白,抑制衣壳组装;作为逃逸策略,非洲猪瘟病毒通过分子模拟劫持细胞自噬系统反过来降解该受体。该研究为开发新型抗病毒制剂提供了新靶标,论文 DOI: 10.1002\u002Fadvs.77741。","[![Image 1: 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[人才](https:\u002F\u002Ftalent.sciencenet.cn\u002F) | [会议](https:\u002F\u002Fmeeting.sciencenet.cn\u002F) | [基金·项目](https:\u002F\u002Ffund.sciencenet.cn\u002F) | [论文](https:\u002F\u002Fpaper.sciencenet.cn\u002F) | [绘图](https:\u002F\u002Fvisual-web.sciencenet.cn\u002F) | [视频·直播](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog.php?mod=video) | [小柯机器人](https:\u002F\u002Fpaper.sciencenet.cn\u002FAInews) | [医学科普](https:\u002F\u002Fyxkp.sciencenet.cn\u002F)\n\n作者：李晨,邓彦莉 来源：中国科学报 发布时间：2026\u002F10\u002F15 11:58:32 选择字号：小 中 大 研究揭示非洲猪瘟病毒与宿主“攻防”机制 近日，中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装，以及病毒如何“反击”的分子机制。相关研究成果发表在《先进科学》（_**Advanced Science**_）上。 内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。 该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。 该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。 相关论文信息：https:\u002F\u002Fdoi.org\u002F10.1002\u002Fadvs.77741 版权声明：凡本网注明“来源：中国科学报、科学网、科学新闻杂志”的所有作品，网站转载，请在正文上方注明来源和作者，且不得对内容作实质性改动；微信公众号、头条号等新媒体平台，转载请联系授权。邮箱：shouquan@stimes.cn。\n\n打印 发E-mail给：\n\n以下评论只代表网友个人观点，不代表科学网观点。\n\n[![Image 2](https:\u002F\u002Fnews.sciencenet.cn\u002Fimages\u002Fnewcomm.gif)](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtml\u002Fcomment.aspx?id=572939)\n\n相关新闻 相关论文\n*   1\n*   [微型机器人靶向心脏感染病灶精准送药](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572918.shtm)\n\n*   2\n*   [这个打破常识的发现因何而来](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572917.shtm)\n\n*   3\n*   [科学家捕获最远快速射电暴](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572916.shtm)\n\n*   4\n*   [罗先刚院士：科技创新下一程，不是“接力赛”！](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572915.shtm)\n\n*   5\n*   [研究显示：孕期慢性压力会改变胎盘影响胎儿大脑发育](https:\u002F\u002Fnews.sciencenet.cn\u002Fhtmlnews\u002F2026\u002F10\u002F572914.shtm)\n\n*   6\n*   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[更多>>](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog.php?mod=recommend)\n\n* * *\n\n近日，中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装，以及病毒如何“反击”的分子机制。相关研究成果发表在《先进科学》（_**Advanced Science**_）上。\n\n内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。\n\n该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。\n\n该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。\n\n相关论文信息：https:\u002F\u002Fdoi.org\u002F10.1002\u002Fadvs.77741","中国农业科学院哈尔滨兽医研究所 2026-10-15","2026-10-15T00:00:00Z",83,{"impact":17,"substance":17,"depth":18,"authority":67,"freshness":55,"relevant":21,"comment":68},15,"国家级科研机构在顶刊发表非洲猪瘟攻防机制新发现，为新型抗病毒制剂提供靶标，专业增量明确，但属基础研究、时效稍弱，可入精选。",[70],{"name":63,"url":60},[72,27,73,74,75],"动物疫病防控","内质网自噬","病毒与宿主互作","抗病毒靶标",{"code":31,"slug":32,"name":33,"path":34,"parent_code":35},[],{"status":38,"locked":14,"version":39,"method":40,"evidence":79},{"candidates":80,"agricultural_evidence":45},[81],{"code":31,"score":82,"supported":45,"title":83,"abstract":84,"tags":85},13,[27],[27],[72,27],[87,88],"哈兽研 非洲猪瘟 衣壳组装","非洲猪瘟病毒 内质网自噬","哈兽研非洲猪瘟衣壳组装-5338",0,"2026-10-20T02:47:43.543999Z",{"id":93,"title":94,"url":95,"summary":96,"summary_zh":8,"content":97,"source_name":98,"source_url":8,"published_at":99,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":65,"score_detail":100,"sources":102,"tags":104,"primary_topic":108,"secondary_topics":109,"classification":110,"search_phrases":122,"slug":125,"view_count":90,"doi":8,"paper":8,"created_at":126},5209,"中国农科院哈尔滨兽医所揭示非洲猪瘟病毒与宿主\"攻防\"新机制","https:\u002F\u002Fhvri.caas.cn\u002Fxwzh\u002Fmtbd\u002F8445b415e6c8458a9754862c223d45eb.htm","中国农业科学院哈尔滨兽医研究所揭示内质网自噬如何抑制非洲猪瘟病毒衣壳组装及病毒如何\"反击\"的分子机制,研究发现病毒通过分子模拟劫持细胞自噬系统,拮抗受体抗病毒功能,为开发新型抗病毒制剂提供新靶标,研究成果发表于《Advanced Science》。","近日，中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示了内质网自噬如何抑制非洲猪瘟病毒衣壳组装，以及病毒如何“反击”的分子机制。相关研究成果发表在《先进科学（Advanced Science）》上。\n\n内质网如同蛋白质的生产“车间”。当受损或多余蛋白质出现时，细胞会启动内质网自噬进行清理，这一过程由关键受体分子负责。该研究通过体内外实验发现，这种关键受体介导的内质网自噬能够降解非洲猪瘟病毒的衣壳蛋白，抑制衣壳组装，从而发挥抗病毒功能。作为逃逸策略，非洲猪瘟病毒则通过“分子模拟”劫持细胞自噬系统，反过来降解该受体，从而拮抗其抗病毒功能。该研究为拓展非洲猪瘟病毒与宿主相互博弈的认知及开发新型抗病毒制剂提供了新靶标。\n\n该研究得到国家自然科学基金、黑龙江省自然科学基金和中国农业科学院青年创新专项等项目支持。（通讯员 邓彦莉）","中国农业科学院哈尔滨兽医所(2026-10-12)","2026-10-12T00:00:00Z",{"impact":17,"substance":17,"depth":18,"authority":67,"freshness":55,"relevant":21,"comment":101},"国家级科研机构在非洲猪瘟基础研究上取得新机制发现，专业增量明确，对生猪疫病防控有潜在价值，值得进入每日精选。",[103],{"name":98,"url":95},[72,27,105,106,107],"生猪养殖","病毒学","抗病毒制剂",{"code":31,"slug":32,"name":33,"path":34,"parent_code":35},[],{"status":38,"locked":14,"version":39,"method":40,"evidence":111},{"candidates":112,"agricultural_evidence":45},[113,117],{"code":31,"score":82,"supported":45,"title":114,"abstract":115,"tags":116},[27],[27],[72,27],{"code":118,"score":21,"supported":14,"title":119,"abstract":120,"tags":121},"C1",[],[],[105],[123,124],"哈尔滨兽医所 非洲猪瘟 衣壳组装","非洲猪瘟 内质网自噬 分子机制","哈尔滨兽医所非洲猪瘟衣壳组装-5209","2026-10-18T00:05:22.874379Z",{"id":128,"title":129,"url":130,"summary":131,"summary_zh":8,"content":132,"source_name":133,"source_url":8,"published_at":99,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":134,"score_detail":135,"sources":138,"tags":140,"primary_topic":143,"secondary_topics":144,"classification":145,"search_phrases":152,"slug":155,"view_count":21,"doi":8,"paper":8,"created_at":156},5039,"中国农科院哈尔滨兽医所揭示非洲猪瘟病毒与宿主\"攻防\"新发现","https:\u002F\u002Fwww.caas.cn\u002F?id=99\u002F","中国农业科学院哈尔滨兽医研究所猪烈性传染病创新团队揭示内质网自噬如何抑制非洲猪瘟病毒衣壳组装,以及病毒如何\"反击\"。研究阐明宿主细胞利用自噬机制对抗ASFV衣壳组装的细节,为非洲猪瘟疫苗与抗病毒策略研发提供新靶点。相关成果揭示病毒与宿主之间的精细\"攻防\"博弈,推动非洲猪瘟防控关键技术储备。","[人民日报头版头条]力度更大 “四个面向”为基础研究划重点（总书记的关切·落地的回响）\n\n7月10日，海南商业航天发射场，长征十号乙运载火箭首飞成功，我国运载火箭首次实现可控回收。中国航天一次次创造历史，离不开材料制备、流体动力、空间物理等方面的基础研究突破。","中国农业科学院哈尔滨兽医研究所 2026年10月12日",77,{"impact":17,"substance":18,"depth":136,"authority":67,"freshness":55,"relevant":21,"comment":137},16,"国家级科研机构关于非洲猪瘟病毒与宿主互作机制的新发现，专业性强、信源权威，对动物疫病防控有参考价值，但发布已过数日且属基础研究，时效与产业影响有限。",[139],{"name":133,"url":130},[72,27,141,142,74],"基础研究","兽医科技",{"code":31,"slug":32,"name":33,"path":34,"parent_code":35},[],{"status":38,"locked":14,"version":39,"method":40,"evidence":146},{"candidates":147,"agricultural_evidence":45},[148],{"code":31,"score":82,"supported":45,"title":149,"abstract":150,"tags":151},[27],[27],[72,27],[153,154],"哈尔滨兽医所 非洲猪瘟 内质网自噬","非洲猪瘟病毒 衣壳 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